This drawing was most likely for Series One of 'Pygmalion and the Image', which had been commissioned by the sitter's mother, Euphrosyne Ionides Cassavetti (currently in the Collection of Lord Lloyd-Webber).
Rossetti letter to Madox Brown 23 January 1869: Poor Ned's affairs have come to a smash altogether, and he and Topsy, after the most dreadful to-do, started for Rome suddenly, leaving the Greek damsel beating up the quarters of all his friends for him and howling like Cassandra. Georgie stayed behind. I hear to-day however that Top and Ned got no further than Dover, Ned being so dreadfully ill that they will probably have to return to London.
In January 1869 his wife Georgina found a letter from Maria in his clothing and Burne-Jones reluctantly ended the affair.